"It’s the perfect scapegoat for that creeping feeling so many of us have that our modern world — with our phone addictions and plastic-filled kitchens and pantries stocked with ultraprocessed foods — is slowly poisoning us. For as much as influencers love to talk about inflammation, I had no idea how to picture it. When I ate bread, I imagined my gut swollen and angry. I wondered if a sudden rash on my chin was really a sign that my entire immune system was out of whack. I considered how bad things would have to get for me to give up tomatoes.... One dietitian I spoke to pointed out that, technically, the act of eating anything is inflammatory. In fact, even exercise causes inflammation. When you lift weights, you cause little tears to the muscle that have to be repaired; that process is what grows the muscle. In other words, the inflammation is kind of the point.... Perhaps the only thing that became clear to me was that inflammation is an inevitable part of being alive...."
From "How Inflammation Took Over the Internet/Influencers constantly talk about how to avoid it. But no one quite seems to agree on what it is" (New York Magazine).

44 comments:
It came as news to me that there is such a thing as the Director of Culinary Medicine, Yale School of Medicine. That would be Nate Wood, MD, MHS, Chef, DipABLM, DABOM. His official portrait makes him look like a chorus boy.
I feel that way too. I picture it infection—the puffy painful redness around a poorly-treated wound. But lately it seems to have become an umbrella term for everything that feels wrong in your hody, even when your overall health is good.
for 5000 years, EVERBODY eat wheat..
Now, in the last 50 (5?) years.. MOST PEOPLE are allegic to wheat?
I contracted PMR (polymyalgia rheumatica) this past April when I turned 70. The inflammation caused me to think I was dying, on my way out. It's under control for the time being. When I looked it up, it has been known to hit men when they turn 70. FML.
I'll add onto Gilbar's statement. My wife is celiac and so, yeah...our lives have been a constant game of "where's the gluten?". And we've often been told and have seen in videos that the pasta and bread in Italy uses a more pure form of wheat that even celiacs can eat. Who knows? We intend to try it out someday. But the 'inflammation' discussion has been around this household for years now. Unsurprisingly, it's been amplified and projected over the years through White Women. Not sure how that always happens. Perhaps they are best equipped to hone in on details that center around health. Or...perhaps something else, less science based.
Anyway...immune system issues, anti-inflammatory foods...all of this is interesting and I think there is something to it. I've seen my wife go from suffering to amazing health in giving up gluten over 20 years now. And me? I do my best to keep the gluten industry in business. Pass the pizza, please. My inflammation is getting a bit low.
But...haven't we always had 'nutritionists' around? Are they now considered lower level to Directors of Culinary Medicine?
Chronic inflammation is the problem. Inflammation is a normal part of the body trying to heal itself - when you get a cut, localized inflammation helps in the healing process. But when you have chronic inflammation, it is a signal that the body is failing to resolve whatever it was that triggered the inflammatory response. I am presently dealing with a no-cartilage-left hip (surgery in February) that all of the healing response I can muster will not fix - the body won't grow the cartilage back - and the inflammation that it triggered has left me rashy and has negatively affected my stomach and gut.
Inflammation was Tom Brady’s thing. Will never live down the I never ate a strawberry…
Tommy said what I would have in his opening clause.
It’s the perfect scapegoat for that creeping feeling so many of us have that our modern world — with our phone addictions and plastic-filled kitchens and pantries stocked with ultraprocessed foods — is slowly poisoning us.
When they started telling people smoking was killing them people had the same reaction.
tommyesq said...
Chronic inflammation is the problem. Inflammation is a normal part of the body trying to heal itself - when you get a cut, localized inflammation helps in the healing process. But when you have chronic inflammation, it is a signal that the body is failing to resolve whatever it was that triggered the inflammatory response.
This is the real issue.
Insulin isn't the problem. Insulin resistance is the problem.
gilbar said...
for 5000 years, EVERBODY eat wheat..
Now, in the last 50 (5?) years.. MOST PEOPLE are allegic to wheat?
Go find graphs for brain to gut ratio. Bone density. There are a variety of them.
About 12000 years ago our brain to gut ratio peaked. It has been declining ever since. Just go down to Cosco and tell me where you think our brain to gut ratio is going.
What do you suppose happened 12000 years ago?
We are in an experiment to try to turn people back into cows. So far it we have given it 12000 years.
I prefer the hunter gatherer paradigm of diet that we were on for thousands of years before that.
Temujin said...
But...haven't we always had 'nutritionists' around? Are they now considered lower level to Directors of Culinary Medicine?
All of the scientific literature on diet since the 1950s is just loaded with survey data garbage. Most of it paid for by the sugar and corn industries.
Regarding inflammation, I recently started supplementing with Glycine and NAC. The body supposedly use those two amino acids to make Glutathione which is an antioxidant. I haven't noticed any significant difference, but I've only been doing it for a few weeks.
"Achilles said...
We are in an experiment to try to turn people back into cows. So far it we have given it 12000 years."
There waw a Russian scientist who bred foxes over many generations of the foxes. He only allowed the friendliest foxes to breed. The foxes grew more docile and neotenous with each generation. Scientists have examined human skeletal remains from before agrarian society developed and discovered they showed signs of higher testosterone levels, thicker more developed brows, jaws etc. There is a theory among some that Human civilization is an act of humans domesticating themselves. When we domesticate other animals they typically become more docile and gentle, but they also become less intelligent.
I came here to learn. Today, I didn't learn anything about inflammation, but that page, after the article on inflammation, I noticed there is an article about "Gay Hockey Smut".
That's something I didn't know.
Tmi lf you look at her previous work she knows nothing
The Vault Dweller said...
There is a theory among some that Human civilization is an act of humans domesticating themselves. When we domesticate other animals they typically become more docile and gentle, but they also become less intelligent.
That is a good hypothesis.
I would extend that to say that most of human history has been some humans trying to domesticate other humans.
I think there is a movie about that. Probably several.
There are many reasons why they want vegetarians and bug eaters.
While there is no scientific consensus that American wheat is inherently more inflammatory than European wheat, many experts and anecdotal reports suggest that the agricultural and processing differences may contribute to inflammation and digestive issues for sensitive individuals. Scientific studies have not substantiated claims of metabolic differences in the wheat itself. Potential contributing factors to perceived differences in inflammation include:
Gluten Content: Most American wheat products are made from hard red wheat, which has a higher gluten content than the soft white wheat or spelt varieties more commonly used in Europe. Some American manufacturers also add extra gluten to products to improve texture and shelf life, further boosting levels. For those with non-celiac gluten sensitivity, higher gluten levels may cause more symptoms.
Agricultural Chemicals: The herbicide glyphosate (active ingredient in Roundup) is used widely on American wheat crops, sometimes as a desiccant just before harvest. While the EPA claims it is safe for human consumption at current levels, some research suggests glyphosate residue may disrupt the gut microbiome and potentially increase inflammation. While the EU has not banned all glyphosate use, many European countries have stricter regulations and lower residue limits.
Processing and Additives: American flour is often stripped of nutrients during processing and then "enriched" with synthetic vitamins and iron, some of which (like certain forms of iron or folic acid for those with MTHFR gene mutations) can cause issues for some individuals. American products also often contain additives, preservatives, and bleaching agents (like chlorine gas and potassium bromate) that are banned in many European countries, which can contribute to gut irritation and inflammation.
Baking Methods: Traditional European baking often involves longer fermentation processes, such as sourdough leavening, which can break down some of the proteins and FODMAPs (fermentable short-chain carbohydrates that cause bloating) in the flour, making the final product easier to digest.
It is important to note that individuals with diagnosed celiac disease should avoid all forms of gluten, regardless of the country of origin, as it will always cause intestinal damage.
I remember being coached about 'inflammation' as much as 20 years ago, by one of those chiropractors that does hair testing analysis and sells vitamins, and uses muscle testing.
Which means that this is non-traditional medicine, if you're being kind, or quackery, if not.
If you can't measure it, and if there are no parameters used to track it, then it 'might' exist as a condition. Medical science has not yet conquered health, so other forms of medicine are still a viable concept.
For instance, I once had a case of 'Popeye elbow' bursitis, where your elbow bursa swells up like a golf ball. Western medicine says, it'll go down after a few weeks. Or, you can try draining it, which uses a large needle and might not work (spongey mass). Or, you can cut. Instead, my accupuncturist 'circled the dragon', with needles, and it started going down the next day.
So, inflammation probably exists as a condition, and we've all felt a kind of malaise from time to time that can be ascribed to it. But if it's not measurable, then western medicine can't treat it, unless using placebos.
Math is hard, human biochemistry is relatively simple. Garbage in, Garbage out.
Mechanisms of Inflammation
Gut dysbiosis—an imbalance in the composition and function of the gut microbiota—triggers pathological inflammation through several mechanisms:
Intestinal Barrier Dysfunction: Dysbiosis can damage the integrity of the intestinal epithelial barrier, a condition often referred to as "leaky gut". This compromised barrier allows bacteria, their products (like lipopolysaccharides or LPS), and toxic metabolites to translocate from the gut lumen into the bloodstream and other tissues.
Immune Dysregulation: The gut microbiota plays a vital role in training and regulating the immune system. An imbalance can lead to an overactivation of pro-inflammatory immune responses (e.g., T helper 17 cells and M1 macrophages) and a reduction in anti-inflammatory responses (e.g., regulatory T cells and M2 macrophages).
Production of Pro-inflammatory Mediators: Opportunistic pathogens that thrive during dysbiosis can produce toxins and other molecules (pathogen-associated molecular patterns) that bind to host receptors like Toll-like receptor 4 (TLR4). This interaction activates inflammatory signaling pathways (like NF-κB) and leads to the release of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukins (IL-1β, IL-6), which drive inflammation.
Altered Metabolite Production: Beneficial bacteria typically produce anti-inflammatory metabolites like short-chain fatty acids (SCFAs), which help maintain the gut barrier and immune balance. Dysbiosis often results in a decrease in these beneficial metabolites and an increase in harmful ones, further promoting inflammation.
Gut dysbiosis is caused by a range of both external and internal factors that disrupt the balance of microorganisms in the gut, leading to a loss of beneficial bacteria, an overgrowth of harmful bacteria, and a reduction in overall microbial diversity. The most significant contributing factors include dietary choices, antibiotic use, and chronic stress.
Key Causes of Gut Dysbiosis
Diet: A primary driver of gut dysbiosis is a long-term, unhealthy diet.
High intake of: Saturated fats, simple sugars, refined carbohydrates, and food additives, often found in Western or ultra-processed diets, can promote the growth of harmful bacteria.
Low intake of: Dietary fiber (prebiotics) and various plant-based nutrients can starve beneficial bacteria that rely on this fiber for energy and anti-inflammatory short-chain fatty acid (SCFA) production.
Medications: Certain medications, especially broad-spectrum antibiotics, can rapidly reduce the diversity and population of beneficial bacteria in the gut. Other drugs like proton pump inhibitors (PPIs) and some non-steroidal anti-inflammatory drugs (NSAIDs) can also alter the gut environment.
Physical and Psychological Stress: Chronic physical or psychological stress can disrupt the gut-brain axis, leading to increased intestinal permeability ("leaky gut") and a compromised immune response, which in turn promotes an imbalance in gut flora.
Infections and Inflammation: Infections from pathogens can trigger an inflammatory response that alters the gut environment, favoring the growth of certain harmful bacteria (pathobionts) that thrive in inflamed conditions.
Lifestyle and Environmental Factors:
Alcohol and Tobacco: Heavy use of alcohol and smoking can negatively impact the composition of the gut microbiome.
Environmental Toxins: Exposure to pollutants and lingering pesticides on food can poison the microbiome.
Lack of Exercise: Physical inactivity has been associated with alterations in bacterial composition.
Host Factors: Genetics, age, and mode of birth (vaginal vs. C-section) can predispose individuals to dysbiosis, although environmental factors typically have a more dominant impact later in life.
Life'll kill ya.
The solution isn't a or surgical intervention. It certainly isn't the right vitamin or supplement being sold by influencers with six packs and perfect teeth.
It's doing the every day hard work of impulse control, a real food diet, exercise, meaningful relationships, a connection to nature, having a purpose in life.
Life will cripple you, slow you down, injure you, make you miserable to the point when death seems like a better alternative. Sure, having a healthy lifestyle will not prevent your death it might not even prevent your decline and suffering at the end, but it's the best shot you have at being relatively healthy for as long as possible.
We live in a free country, people are free to Stew in their own juices. Just quit your bellyaching because it's all one giant self-inflicted wound.
"The Vault Dweller said...
Regarding inflammation, I recently started supplementing with Glycine and NAC. The body supposedly use those two amino acids to make Glutathione which is an antioxidant. I haven't noticed any significant difference, but I've only been doing it for a few weeks."
I have had both hips replaced, and have arthritis in both knees (4 knee operations). I also have severe arthritis in my right ankle. At 68 also have the normal body aches. All this, inflammation is real and an issue.
I started taking liposomal glutathione. The liposomal variant is important as the coating allows survival through the stomach providing better absorption. It seems to work, and well. I don't feel 28, but everything is much better and easier.
"Howard said...
Gut dysbiosis is caused by a range of both external and internal factors that disrupt the balance of microorganisms in the gut, leading to a loss of beneficial bacteria, an overgrowth of harmful bacteria, and a reduction in overall microbial diversity. The most significant contributing factors include dietary choices, antibiotic use, and chronic stress."
I got two surgical infections from my second hip replacement, and have been on antibiotics since, 8 years now. For now, I'll probably be on them forever. I take a strong probiotic daily, Florigen Digestive, which helps.
Howard said...
While there is no scientific consensus that American wheat is inherently more inflammatory than European wheat, many experts and anecdotal reports suggest that the agricultural and processing differences may contribute to inflammation and digestive issues for sensitive individuals.
The same is true for US dairy vs. European dairy.
Howard said...
The solution isn't a or surgical intervention. It certainly isn't the right vitamin or supplement being sold by influencers with six packs and perfect teeth.
It's doing the every day hard work of impulse control, a real food diet, exercise, meaningful relationships, a connection to nature, having a purpose in life.
At least they aren't trying to sell us chicken and rice and broccoli anymore.
I'm sorry to hear that George. I feel lucky I had a double hip replacement 25 years ago and they are still performing like they are brand new (knocks the top of head for luck). I'm glad to hear you're having a beneficial effect from the supplement.
I am currently 65 years old and work my ass off full time at a retail job. I wouldn't be able to do it without completely changing my diet to gut health focused. I'm on zero medications except for the occasional Tylenol or Aleve or Zyrtec.
My advice to you and anybody listening is whatever ails you, keep working the problem. You may not find the solution but at least it will keep you distracted from the misery and pain.
Curious George said...
I started taking liposomal glutathione. The liposomal variant is important as the coating allows survival through the stomach providing better absorption. It seems to work, and well. I don't feel 28, but everything is much better and easier.
I am going to recommend a BPC-157/TB500 blend for a cycle post injury/surgery.
Yeah, Achilles. Completely different genetics. Also I think that the real impact from America's love affair with glyphosate is the primary biodegradation byproduct, aminomethylphosphonic acid (AMPA). This type of chemical strongly bonds with organic carbon. No doubt that a lot of the vegetables that are sprayed with this garbage hold this poison tightly:
"Foods with high levels of AMPA (Aminomethylphosphonic Acid, a breakdown product of the herbicide glyphosate) are typically conventional (non-organic) grains, soy products, fast-food items, and some legumes, with specific high-risk items including whole wheat bread, bagels, oats, hummus, and pizzas, often linked to processed foods and high-grain diets, according to studies showing significant dietary sources. "
"Howard said...
I'm sorry to hear that George. I feel lucky I had a double hip replacement 25 years ago and they are still performing like they are brand new (knocks the top of head for luck)."
It's only been 8 years for me, but they're fine. Everything else hurts....
Peptides are interesting. Big Pharma is figuring out how to monetize BPC-157 via FDA approval.
"Aggie said...
So, inflammation probably exists as a condition, and we've all felt a kind of malaise from time to time that can be ascribed to it. But if it's not measurable, then western medicine can't treat it, unless using placebos."
Snake oil has anti-inflammatory properties as well.
A lot of medicine is about “capturing an idea.” That is, psychology of placebo. My medical issues so far have been deterministic, broken bones, infection, and such, mechanical things. I have seen people wish themselves sick so there is something else to it other than physics.
Talking about plastic. Our cat used to love to eat plastic. Especially the little plastic threads on bags of lemons or potatoes. We didn't know he was doing it until we had to take him to the vet.
He had a ton of plastic in his stomach. Talk about inflamation!
Its really a downer that alcohol and steak aren't healthy.
Howard said...
Peptides are interesting. Big Pharma is figuring out how to monetize BPC-157 via FDA approval.
You can make your own with about 100,000$ worth of equipment. Big Pharma has been trying to kill this in its crib for a while. Big Pharma is fighting all of this as hard as they can but it is a losing battle.
Ozempic/Wegovy are available on a dozen websites right now for ~100$ a month. The drug companies are massively overdosing people with GLP1s. GLP1s have been used in 50 other countries for decades at way lower doses.
I believe they are doing it to cause health problems and get peptides in general banned.
I know several members of my extended family who are moving to China because their health care system is so much better and more affordable than ours is.
I'm still waiting for my late-September knee replacement to reach the level of "I'm glad I did this." The post-surgical pain in that knee has almost entirely subsided (still a couple of positions I can get into that zing me), but the stiffness still feels like the other, also-arthritic knee after taking a big ol' anti-inflammatory dose of Advil.
Meanwhile, the unreplaced knee's early-September hyaluronic gel injections have worn off and THAT knee is making me wince and groan and take ten minutes to start walking normally again. And, joy of joys, add a good sciatica flare-up that hits a mile into any walk I take and keeps me from sleeping on my left side, which has to be officially diagnosed and dealt with before my surgeon will consider replacing that knee.
I'm feeling as if I'm living through my own decline right now! And I have six years to Medicare.
Don't get me started on "toxins".
RCOCEAN II said...
Its really a downer that alcohol and steak aren't healthy.
Corn fed steak is not good for you.
Grass fed steak is what you were meant to eat.
Yes there is a difference. People don't understand how poisonous grains are to any animal that does not have a GI tract meant to eat them. Corn fed beef is fattier and contains the same poisons they were fed. The fatty acids in a corn fed cow are different and bad for you.
Lectins are a poison plants have been developing for millions of years. Gluten is a defense mechanism for plants. It makes animals that eat it feel bad.
If you feed cows corn you will get fat unhealthy cows. If you eat fat unhealthy cows you will get unhealthy fats the cows packed into their muscles while their immune systems were trying to clean the lectins and other anti-nutirents in their blood they were fed to make them fat.
There is also the trenbolone issue.
While lots of things are inflammatory these days (food, exercise, environmental chemicals, rhetoric), at my age I’m more concerned about cooling to room temperature.
@The Vault Dweller said...
'Snake oil has anti-inflammatory properties as well....'
Aaaand... it's Gluten-Free !
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