Althouse: "A single shot of the [Pfizer] vaccine is 85% effective in preventing symptomatic disease 15 to 28 days after being administered..."

February 19, 2021

"A single shot of the [Pfizer] vaccine is 85% effective in preventing symptomatic disease 15 to 28 days after being administered..."

"... according to a peer-reviewed study conducted by the Israeli government-owned Sheba Medical Center and published in the Lancet medical journal. Pfizer and BioNTech recommend that a second dose is administered 21 days after the first. The finding is a vindication of the approach taken by the U.K. government to delay a second dose by up to 12 weeks so it could use limited supplies to deliver a single dose to more people, and could encourage others to follow suit.... "

The Wall Street Journal reports.

254 comments:

«Oldest ‹Older 201 – 254 of 254

DavidUW said...: I’m not ordering you, I’m challenging you and I see you’re unable to rise to the challenge.
>>
So, will you apologize and kiss my ass when i do so, for your challenge, you shriveled up bitch?; 2/19/21, 5:59 PM
DavidUW said...: For Inga, the ignorant slut

https://www.nejm.org/doi/suppl/10.1056/NEJMoa2035389/suppl_file/nejmoa2035389_appendix.pdf
Page 44.
Supplemental data.
"Total infection"
Symptomatic OR RT-PCR+
332 vs. 35

Now kiss my ass you ignorant slut.; 2/19/21, 6:06 PM
Inga said...: This comment has been removed by the author.; 2/19/21, 6:06 PM
gilbar said...: Wasn't there someone here, that went on and on (and on (and on(and on))) about Canada???
How Canada does EVERYTHING right? I think his name was Karen?

Where's he at NOW?
f you’re impatient with the pace of Covid-19 vaccine distribution in the U.S., count your blessings. At least you don’t live in Canada. As of Wednesday, my country had administered only 3.52 vaccine doses per 100 people, according to the University of Oxford’s Our World in Data website. The U.S., at 17.00, was doing almost five times as well. The figures were 80.07 in Israel, 25.04 in the U.K. and 5.40 in the European Union.; 2/19/21, 6:08 PM
Inga said...: “It looks like there aren't many great matches for your search”

LOL; 2/19/21, 6:10 PM
Butkus51 said...: dont get in the pigpen with the pig; 2/19/21, 6:10 PM
Inga said...: ‘don't get in the pigpen with the pig’

Thanks for the advice. I’ll ignore YellerUW from here on in. As I’ve been saying, it’s a waste of time arguing with Trump cultists.; 2/19/21, 6:12 PM
DavidUW said...: Can’t google or copy and paste. Wow Inga a you’re dumber than dirt.; 2/19/21, 6:13 PM
DavidUW said...: Link is right there moron.; 2/19/21, 6:13 PM
DavidUW said...: Weird. Inga not going to apologize ?
Not going to kiss my ass?
Still can’t google?
Still can’t find the New England journal of medicine, the pre eminent US medical journal?
Still can’t copy and paste?

Die in a fire you fuckwit.; 2/19/21, 6:17 PM
Josephbleau said...: "A single shot of the [Pfizer] vaccine is 85% effective in preventing symptomatic disease "

Yes mate, and a single shot (or 3) of Lagavulin 16 year is 100%.; 2/19/21, 6:17 PM
Inga said...: Hey Yeller, how about a hotlink? Googling with cut and paste does not bring it up. Google it yourself and see what you come up with. What’s the matter don’t you know how to make a hotlink?; 2/19/21, 6:19 PM
DavidUW said...: Hey dumb bitch I gave you the journal and the date.; 2/19/21, 6:24 PM
Josephbleau said...: Are you coming to bed you sexy darling? No I have something important to do. Someone on the internet is wrong! Paraphrase of XKCD.; 2/19/21, 6:24 PM
DavidUW said...: Inga you’re fucking old I know you might have seen a library once. Given the name of a journal and the date do you think you’re smart enough to find it?; 2/19/21, 6:25 PM
DavidUW said...: So let me get this straight. Inga you’re so damn ignorant you can’t look up the New England journal of medicine and find an article with an exact date but I’m supposed to take your “challenge” seriously.

Hilarious. Die already.; 2/19/21, 6:31 PM
Josephbleau said...: I give up.; 2/19/21, 6:33 PM
Inga said...: A Shot in the Arm

One thing these vaccines have in common is their route of administration. They are given in one or two doses by intramuscular injection, typically in the upper arm. While this method is common for routine vaccination, such as influenza, it can prove a deterrent in patients with needle phobia (1) or young children. Intramuscular injections often produce a local response, such as pain or swelling at the injection site. A recent report suggests that, while patients may be asymptomatic after COVID-19 vaccination, they can still harbor the SARS-2-CoV coronavirus in the upper airways and be able to transmit infection to others(2).

Intramuscular injections produce a systemic humoral response to a vaccine mediated by B cells, which results in the initial production of immunoglobulin M (IgM) antibodies followed by IgG antibodies. This pathway works in concert with the T-cell immune response. However, in the cases of respiratory viruses like SARS-CoV-2, the first line of defense is the mucosal immune system, in which the response to a pathogen is mediated primarily by IgA antibodies produced by mucosal epithelial cells. In COVID-19 infection, IgA and IgG responses show a negative correlation (3); that is, a strong systemic IgG response to a vaccine may not provide an effective mucosal IgA response.; 2/19/21, 6:58 PM
FullMoon said...: Inga said...

“The studies for both vaccines have been published in the New England journal of medicine.”

So then how hard is it for you to prove your loudmouth yelling that you’ve been doing all day. Provide the link that proves what you assert it says. The onus is on you to prove your assertions. I knew that once someone asked for the link you’d fall apart.

2/19/21, 5:43 PM

Be honest, you saw it coming, right?

Inga said...
..I may have zero proof that c(it)happened, but you also have zero proof that it didn't happen. ...
5/12/17, 3:29 PM; 2/19/21, 7:04 PM
DavidUW said...: Again

The primary data as posted above demonstrated that virus is not found in vaccinated people.

You can hypothesize quoting some opinion piece in a corporate blog or you can go to the New England journal of medicine published supplemental data from the Moderna phase 3 published on February 4 of this year to find the answer

No you will not transmit the virus after vaccination unless your immune system failed to react to the vaccine (about a 5% chance).

Stop being stupid Inga.; 2/19/21, 7:05 PM
Inga said...: We need mucosal immunity. A shot in the arm isn’t giving a significant amount of mucosal immunity.

“The best way to block both viral infection and transmission is by inducing a special type of immune response called mucosal immunity. Mucosal immunity protects the parts of the body that are in contact with the environment, and in the case of a respiratory pathogen, that means the nasal cavity and the lungs. Because it is a localized type of response, a vaccine needs to be delivered to the appropriate compartment if mucosal immunity is to be stimulated. In the case of a respiratory pathogen like SARS-CoV-2 that means intranasal vaccine administration.

Without mucosal immunity, the virus may continue to thrive in a person’s nasal cavity allowing for easy transmission. This is why wearing a mask, even after vaccination with an intramuscular vaccine, will remain critical.

Thankfully, scientists, including our team, are working on next generation vaccines that can elicit mucosal immunity, including intranasal vaccines that have the potential to elicit an immune response in the nose as well as systemically. This type of broader immune response could defend against infection, disease and transmission. In fact, an intranasal vaccine could also be used in combination with an intramuscular vaccine to elicit mucosal immunity and serve as a booster for systemic immunity.”

https://endpts.com/why-mucosal-immunity-may-be-required-to-end-the-pandemic/; 2/19/21, 7:09 PM
Inga said...: A spray up the nose, and a shot in the arm? Or will the nasal spray be sufficient?

“We believe deployment of intranasal vaccines like AdCOVID will be essential to a successful global response to the pandemic,” said Vipin K. Garg, Ph.D., president and chief executive officer of Altimmune. “Developing vaccines that can effectively prevent transmission is a growing imperative to block the spread of disease and combat the emergence of new variants.”

“The vaccine candidate has tantalizing promises, according to Altimmune. No need of refrigeration. Simple one-dose administration by a spray into the nose. The power to elicit mucosal immunity at the linings of the nose and lungs would protect not only against infection but also against transmission. Existing intramuscular COVID-19 vaccines are not known to elicit this kind of immunity,.”; 2/19/21, 7:20 PM
Inga said...: I rest my case.; 2/19/21, 7:20 PM
Original Mike said...: I don't think you're going to get Americans to wear masks once everybody is vaccinated.; 2/19/21, 7:21 PM
DavidUW said...: Hahahahahahahah

Quoting a biotech exec who’s making a competing product
I actually know Vipin. Besides looking like Dracula he’s a crook who failed at his last company
You are stupid.

The data are right there and published.; 2/19/21, 7:24 PM
Josephbleau said...: Our long national nightmare of peace and prosperity is now at an end. Thank you President Tyrebiter!; 2/19/21, 7:24 PM
Inga said...: “I don't think you're going to get Americans to wear masks once everybody is vaccinated.”

All the more reason to get the nasal spray vaccine.; 2/19/21, 7:24 PM
Original Mike said...: "All the more reason to get the nasal spray vaccine"

When is that abailable?; 2/19/21, 7:26 PM
DavidUW said...: 335 control patients developed the ‘rona
35 developed the rona as defined by symptoms OR PCR tests.

Page 44. Supplemental data.

You’re essentially claiming that the 90% difference is due to what?; 2/19/21, 7:26 PM
DavidUW said...: We have mucosal immunity as demonstrated by the lack of positive RT PCR tests from the...mucus in the actual clinical trials.

You can speculate all you want. There are literally now millions of patient years of data showing I’m correct.

Please wait for a nasal vaccine Inga. Hope you die in the meantime.; 2/19/21, 7:29 PM
Original Mike said...: So this nasal vaccine is just a twinkle in a biotech execs eye?; 2/19/21, 7:34 PM
DavidUW said...: Yes.it's a product of Inga's fevered google searching on her new favorite term, "mucosal immunity" in a desperate attempt to try to avoid admitting I'm 100% correct. But she somehow can't find the NEJM, the most prestigious American medical journal.

the intranasal candidate is not even beginning Phase 1 studies yet.; 2/19/21, 7:39 PM
Inga said...: “So this nasal vaccine is just a twinkle in a biotech execs eye?”

“The Altimmune Inc. vaccine candidate that was tested preclinically at the University of Alabama at Birmingham last year is expected to start patient enrollment for its Phase 1 clinical trial next week.

Maryland-based biopharmaceutical company Altimmune announced that the United States Food and Drug Administration has cleared the company’s Investigational New Drug application for its Phase 1 clinical trial of AdCOVID, a novel, single-dose, intranasal COVID-19 vaccine candidate.”

I’m still getting the shot in the arm and when this nasal spray vaccine becomes available, I’ll be in line for that too, if it’s recommended as a booster.; 2/19/21, 7:44 PM
Original Mike said...: "I’m still getting the shot in the arm and when this nasal spray vaccine becomes available, I’ll be in line for that too, if it’s recommended as a booster."

Given my situation, I suppose I'll be in line with you. But once everyone who wants the shot gets it I don't think you'll succeed at keeping people in masks.; 2/19/21, 7:49 PM
FullMoon said...: Whatever. Just be thankful Biden got the vax created and ordered, etc.

GP said: "Biden repeated his favorite new lie that there was no Covid vaccine distribution plan when he got into office.

Thanks to President Trump’s “Operation Warp Speed,” a Covid vaccine was approved and ready to be distributed by October/November.

The Biden Admin inherited Trump’s vaccination program already meeting their target of 100 million shots in 100 days.

Biden actually got vaccinated, twice, before he was sworn into office."; 2/19/21, 7:54 PM
FullMoon said...: But once everyone who wants the shot gets it I don't think you'll succeed at keeping people in masks.

Hopefully someday people will be allowed to decide for themselves whether to go maskless, or wear a mask.Or two, like Biden.

Around here everyone masked. Some out of caution, many because of politeness.; 2/19/21, 7:59 PM
DavidUW said...: Good luck recruiting people to a Phase 3 in a year for the snot shot.

I guess old fraud Vipin can try to recruit ditch diggers in India.

So Inga. Kissed my ass yet?
Still having trouble understanding data?
Got a different snake oil fraudster to quote?; 2/19/21, 8:02 PM
Original Mike said...: "Hopefully someday people will be allowed to decide for themselves whether to go maskless, or wear a mask."

After getting vaccinated I don't think people will be asking for permission.; 2/19/21, 8:05 PM
DavidUW said...: Inga, still pretending you can't find www.nejm.org?

What's your next attempt to ignore the actual data?; 2/19/21, 8:06 PM
Inga said...: Yeller, why don’t you go and cut and paste the actual quote you keep yelling about? You don’t even have to make a hyperlink. I’m not wasting my time searching for something you are unwilling to put right here to definitively prove your point. I’m actually texting with my daughters now, so stop yelling at me, I won’t be responding.; 2/19/21, 8:29 PM
Anonymous said...: There are so many smarty-smart people here, bitterly clinging to life. Fearful. Afraid that life, as we know it might end. Well, it does. This life ends in the fullness of our time.

It just does. We rarely see it coming. It just...ends.

Ask yourself this: If I were to die next week, (you might) what have I not done, that I would have wanted to do? I'm not talking about a stupid bucket list. I'm talking about the detritus that sits at the bottom of our minds, that we think we have forever to resolve.

Stir it up. Bring it to the surface. Deal with it now, or take it with you.

Burma Shave.; 2/19/21, 8:30 PM
DavidUW said...: Inga I gave you a link
I gave you the exact journal and date
I gave you the data table

You must be illiterate.

But somehow you can google mucosal immunity just fine; 2/19/21, 8:43 PM
DavidUW said...: Do you sit with your fingers in your ears like your grandkids and scream lalalala when you refuse to read something that contradicts your foolishness.

No fool like an old fool; 2/19/21, 8:45 PM
DavidUW said...: Have time to google mucosal immunity but not the primary data source that you claim is wrong.

Idiot Inga unable to handle the truth.

The truth is she's wrong. And stupid.; 2/19/21, 8:48 PM
Josephbleau said...: This blog has seriousness and value, yet the individuals make it more tedious than a Biden speech. Perhaps no one cares.; 2/19/21, 9:08 PM
iowan2 said...: Inga said...
We need mucosal immunity. A shot in the arm isn’t giving a significant amount of mucosal immunity.

AAAnnnnddd....goal posts moved.

Of course the remote chance that a vaccinated person could transmit the virus is yet another red herring.
WHO CARES? All the vulnerable persons have been vaccinated. Let the virus spread, it is not particularly dangerous at this point.

Take the win.

(this would be a lot easier of we had a common defined goal.); 2/19/21, 9:58 PM
The Godfather said...: I keep reading that a significant number of regular folks aren't planning to get vaccinated. By "regular folks" I mean people who appear to be acting in what they think is a reasonable manner, rather than just trying to make an ideological or political point. There are probably too many of them to force them to be vaccinated, so what do we do?

I think a large part of the problem is that the public health professionals are so used to being overly caustious in what they say or promise that they are scaring people about the vaccine's risks, and underselling its benefits. I'm elderly, and it was a no-brainer for me to get my shots as soon as I could. I know people of about my age who have gotten very sick from Covid, and a couple who died either from or with covid.

But what about younger, healthy people? Why should they get the vaccine if (a) they are warned that there may be adverse side-effects (I had none), (b) they could still get covid after being vaccinated (very unlikely), and (c) just to prove point (b) the Government will require them to wear masks and socially distance even after they've been vaccinated?

Yes, I understand that there is SOME risk that vaccinated people will be able to contract a mild form of the disease and possibly pass it on to others. That's the rationale for continuing to require vaccinated people to wear masks and socially distance. But doesn't the unwillingness of many people to get the vaccine cause a greater risk of the disease spreading than the risk of vaccinated people spreading the disease if they don't wear masks and socially distance?

I say: Issue to everyone who has gotten both shots and has tested negative for covid two weeks later a badge to wear that excuses him/her from all masking and social distancing requirements. Make that the law, Pres. Biden, and hardly anyone will refuse to get their shots.; 2/19/21, 10:10 PM
DavidUW said...: Issue to everyone who has gotten both shots and has tested negative for covid two weeks later a badge to wear that excuses him/her from all masking and social distancing requirements. Make that the law, Pres. Biden, and hardly anyone will refuse to get their shots.
>>
Better just to say when cases drop to 5/100k or whatever, all the mask mandates are lifted at the federal level.; 2/19/21, 10:36 PM
Anonymous said...: Hey. Has anybody heard about this new 'pandemic'. I've been out of town so it's the first I've heard about it.

I read that cattle have to strap a handkerchief to their face because they are unable to cover their mouth when they cough or sneeze. Can you believe it? They fart too, so we're all probably going die from climate change! Can you believe it?

But then, I'm told there are 'droplets' than can kill people! The cattle emit these killer droplets when they breathe! Can you believe it?

There's more. Every cow is a toxic disease waiting to kill us? Seriously! If you come within 6 feet of a cow, you will die! Can you believe it?

Wait! There's more! All the cattle are required to be herded into a cattle pen to get a vaccine that changes their RNA permanently! The Scientists say this new vaccine is experimental, and they really don't know what will happen to the cattle a few years from now, but they think it will stop the killer droplets for now. Can you believe it?
Don't worry though. If it doesn't work, the cattle can be 'put down'. Probably better for the environment, anyway.

One thing the Scientists do know is that if the cattle stampede down a street, mooing 'Black Cattle Matter', and breaking windows, then that makes them temporarily immune, and if Joe Biden becomes President, the 'cases' go away. You guys! This is Science!

Can you believe it?; 2/19/21, 11:55 PM
Anonymous said...: DavidUW - "issue to everyone who has gotten both shots and has tested negative for covid two weeks later a badge to wear that excuses him/her from all masking and social distancing requirements.

Where I live, "We don't need no steenking batches. We don't 'mask' and don't 'social distance'. We revel at your docility, your obedience, and your submission, though.
Good boy.

Don't worry about us though. We're all gonna die because there might be a new surge...there might be a new variant...the hospitals might be overwhelmed!!! Science!; 2/20/21, 12:09 AM
walter said...: roesch/voltaire said...my wife who still teaches has not received any shots and does not want to return to the classroom until she has at least one-- which seems reasonable to me. In the mean time we both wear double masks when in public.
--
What age range of students?
and if the double masking works so well....; 2/20/21, 12:15 AM
stevew said...: The more those that ignore the verified data on the virus speak the more convinced I am that I don't need the vaccine. Getting it won't make any difference or eliminate the various lockdown and masking regimes. I do like the "I've Been Vaccinated!" badge idea, can hear the badge black market spinning up as I type this.; 2/20/21, 7:08 AM
stlcdr said...: Gusty Winds said...
At this point, people put on a mask at the grocery store to avoid having their balls busted by some freaked out Teachers Union Karen and their Voltaire husbands . They don’t give a shit about COVID, and they know they’re not going to die from it, nor kill anyone like Democrat Governors did.

Arrrgg...you got me! Now what?; 2/20/21, 9:02 AM
DavidUW said...: DavidUW - "issue to everyone who has gotten both shots and has tested negative for covid two weeks later a badge to wear that excuses him/her from all masking and social distancing requirements.
>>
That wasn't me.
I said I'd prefer a hard standard because as we've seen, there's no motivation for tyrants to do anything but lock down people.
At least if they said, X level of infections and it's over, people would hold them to that.

I'd prefer all masking and lockdown be over because it's clear from CA vs. FL that masks and lockdowns are utterly useless at preventing transmission.; 2/20/21, 10:24 AM