May 28, 2026

"GLP-1 drugs may be rewiring circuits involved not only in appetite but in emotion, desire and beyond."

WaPo reports. Gift link. Excerpt:
Tens of millions of people are now taking the medications worldwide, turning what began as an obesity and diabetes treatment into what could be modern medicine’s largest unplanned neuroscience experiments. Scientists are studying GLP-1 drugs — medications that mimic the hormones involved in appetite, blood sugar and digestion — for how they affect not only eating behavior, but also addiction, cognition, neurodegeneration and even motivation and pleasure....
On social media and at doctor’s offices, some users have reported a type of brain fog and others something broader and harder to define: a strange emotional flattening. People describe less pleasure, less motivation, diminished interest in hobbies and even reduced sexual desire. Those accounts are beginning to raise deeper questions about what, exactly, these drugs are changing. If GLP-1s alter the brain systems involved in reward, craving and motivation, researchers wonder, where is the line between quieting a person’s destructive impulses and reshaping personality itself?...

20 comments:

Dude1394 said...

Sure do wish we were allowed to investigate the Covid shots like this.

tim maguire said...

It's not surprising that a drug that suppresses the appetite might not limit itself to the appetite for food.

Jersey Fled said...

Stop being accountable for your actions. Just take a pill. It’s the American way.

baghdadbob said...

Great! We can look forward to a world of thin, hot, celibate women.

Enigma said...

The next generation of medical optimism and Pollyannish marketing followed by failure and regret. See asbestos cigarette filters, Thalidomide, anti-depressants, Fen-phen, hormone blockers, etc. etc. etc. etc. etc. etc. etc.

The drive for easy solutions never ends. Those with pre-existing impulse control issues (e.g., obese) may have a net positive outcome? Living experimental condition.

Leland said...

Oh geez. The problem with this drug is that it quiets self-destructive impulses and therefore changes one's personality. Well then, it must be banned, and in place, perhaps offer MAID.

Achilles said...

Anyone who reads the WAPO or NYTs to learn something is a fucking retard.

GLP1s have been around for decades and used in other countries. There is extensive research on them.

Yes they affect neuromodulators. This is known. They reduce spikes and drops in dopamine.

The US media and US health system is run by evil people who are lying to you about everything. They are dosing people with 10 times the normal dosage of GLP1s.

It is insane to watch this kind of crap wash up on a major publication. The journalists at the WAPO are morons. The people who read it and believe it are the dumbest people on the planet.

narciso said...

Yes bezos and carlos slims induces rage and apathy

RideSpaceMountain said...

"...a strange emotional flattening. People describe less pleasure, less motivation, diminished interest in hobbies and even reduced sexual desire."

I wonder if there's an effect on ticks that bite those prescribed. Reduced sexual desire in ticks would be highly beneficial. Let's turn those Alpha-Gal Stacy ticks into Beta-Gal frigid feminazi ticks.

Mike (MJB Wolf) said...

Go ahead and experiment with these, fellow Americans. I'm just eating healthy waiting and watching to see what other "unforeseen" side effects come out over time. Look how long it took for the mainstream press to admit the horrendous damage COVID shots are causing!

Mike (MJB Wolf) said...

This story should be cross-indexed with stories about how much we are learning about gut bacteria and how they help regulate our bodies. Changing diets changes the gut. But to what effect?

Never forget doctors insisted stress and spicy foods caused ulcers, it was repeated as gospel, until a scientist proved the bacteria theory by giving himself a peptic ulcer. What are the other unknown unknowns?

Mike (MJB Wolf) said...

Don't even start me on statins!

Eva Marie said...

If the mere smell of coffee can have life changing effects why should we be surprised?

JK Brown said...

As the young comedian at the link below observes about many modern drugs, they are more like potions. "All magic comes with a price". Sure, you're no long suicidal but you can no longer orgasm or something.


Science is Magic | Ruby Setnik
https://www.youtube.com/watch?v=hDkdfnVSA7g&t=362s

Two-eyed Jack said...

So, like they say: Stay Hungry!

Birches said...

I have noticed a lot of people in my periphery losing massive amounts of weight. After my last child almost 3 years ago and stopping nursing, I am heavier than I have ever been not pregnant. Running, my usual exercise, is more difficult with the toddler. So I have been tempted by GLP1s but the idea of losing my libido is too risky. So I'll just eat less.

baghdadbob said...

Birches said...
"I have been tempted by GLP1s but the idea of losing my libido is too risky. So I'll just eat less."

On behalf of all men, I'll state we'd rather have you plump and horny, than hot and not.

Birches said...

@baghdad bob

That's what my husband thinks too

Achilles said...

Most of the side effects are from people taking 10 times the effective dose.

You can almost always get the benefits and fewer side effects if you take the doses that have been used in other countries for decades.

CJinPA said...

It's like laser eye surgery. Took us a while to realize the lasers were searing little holes in our brains. I'm slightly dumber but I look better. I'd do it again.

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