Here’s why scientists think it works: When someone takes a psychedelic, there is a decrease in blood flow and electrical activity in the brain’s “default mode network,” a group of brain structures found in the frontal and pre-frontal cortex. The default mode network is primarily responsible for our ego or sense of self; it “lights up” when we daydream or self-reflect.Note the quick jump from "mystical experience" to "therapeutic outcomes." Disrespect for religion is an undercurrent to this discussion, which assumes the legal use would entail the assistance of medical professionals. The article quotes drug-policy expert Mark Kleiman, who "emphasizes the importance of containing the experience, both during the trip, for the purposes of safety, and afterward, 'so it’s not merely a one-off mystical experience, but actually something you could build a life around.'"
When we trip, our default mode network slows down. With the ego out of commission, the boundaries between self and world, subject and object dissolve. These processes may be related to something called the “primary mystical experience,” a phenomena highly correlated with therapeutic outcomes. As Matthew Johnson, a principal investigator in Johns Hopkins’s psilocybin studies, explains, these experiences include a “transcendence of time and space,” a sense of unity and sacredness and a deeply felt positive mood.
You can't build your life around a religious experience?