I listened to the whole thing — here — after seeing (on Instapundit and elsewhere) that she got "testy."
"Testy" is an interesting word to use to describe a woman. To me, it resonates with Hillary Clinton's discussion, in the "Fresh Air" interview, that as Secretary of State she was regarded, in those countries that don't recognize women's rights, as an "honorary man." ("When you're a secretary of state, as [Condoleezza] Rice and Madeleine Albright and I have discussed — it's perhaps unfortunate, but it's a fact — that you're treated as a kind of an honorary man or a unique woman who comes from another place outside of the religion, outside of the culture.")
But I'm indulging in etymological guesswork and can only insinuate that writers who use the word "testy" to disparage Hillary imagine — as I did — that there is a connection to the word "testicles." In fact, the word — which the (unlinkable) OED defines as meaning "Prone to be irritated by small checks and annoyances; impatient of being thwarted; resentful of contradiction or opposition; irascible, short-tempered, peevish, tetchy, ‘crusty’" — is derived from the Latin word for head, which relates to being "headstrong" or "obstinate" (which is the older and obsolete meaning of "testy").
It's true that the interview gets more intense at one point, on the subject of same-sex marriage, but that is because Terry Gross (the interviewer) decides to keep following up, probing, in an effort to get Hillary to concede that, years ago, she covered up her support for same-sex marriage because it was politically opportune. Gross was trying to pin something on her, and I liked it that Hillary noticed and, in the midst of eloquently elaborating her thought-out talking points on marriage equality, turned on a dime and put Gross in her place.
We need that kind of sharpness on our side. You can't be sliding along, acting amiable, when you're talking to Vladimir Putin. I want someone with that kind of mental and verbal skill working for us.