Scientists from the Food and Drug Administration’s Division of Applied Regulatory Science carried out a randomized double-blind placebo-controlled trial last year to assess how low-dose CBD affects liver function in a group of healthy middle-aged men and women.... The goal was to give them a typical amount that might be used by consumers.... While the vast majority of people in the trial were unaffected, 5% showed greatly elevated levels of the liver enzyme aminotransferase, a known marker of liver cell damage or inflammation.... Women appeared to be more vulnerable than men....
१० जुलै, २०२५
"Even low doses of CBD may cause harm to the liver in some people, FDA study finds."
NBC News reports.
पोस्ट्स
५७ टिप्पण्या:
How does that compare to the damage that alcohol or acetaminophen does?
"While the vast majority of people in the trial were unaffected, 5% showed greatly elevated levels of the liver enzyme aminotransferase, a known marker of liver cell damage"
interesting use of numbers.
If 5% of alcohol users (or tobacco users) were affected,
would we say "the vast majority are unaffected"
one out of twenty seems pretty high
I've now met a couple dozen people experimenting with CBD and genuine cannabis in an attempt to wean themselves off of prescription meds with unpleasant side effects.
Anecdotally, a third found it a totally effective replacement, another third partially effective, and the final third found it no help at all.
It's an area worthy of rigorous study, that is if Pharma doesn't submarine the investigation.
Even low doses of alcohol cause liver damage in some people.
Women hardest hit - seems to be true for once. I'm glad people are doing more medical research into MJ and its heath effects. It should be obvious that any mind alterting drug will affect your health if used in signifcant quantities. You're basically poisoning your body.
But Big MJ (talk about evil corporations) wants you to think its safe, harmless and maybe even good for you (LOL).
This is actually connected to the previous post about men feeling worthless due to the lack of careers and good jobs. Just medicate them with MJ, Booze, and Porn. That seems to be the Plan.
Remember, NBC News are the ones who built Matt Lauer a rape room where he could lock the door with a secret switch they built under the top of his desk to trap the women inside the rape room.
They also spiked news articles critical of Harvey Weinstein, noted rapist.
Joe Rogan hardest hit.
🤖: “Joe Rogan, the popular podcast host, comedian, and martial artist, has been a vocal advocate for the benefits of CBD. He has discussed it extensively on his podcast, "The Joe Rogan Experience," and has even collaborated with companies to launch CBD products.”
Meanwhile, "approximately 41.9% of adults aged 20 and over had obesity between 2017 and March 2020. This translates to over 100 million individuals." Which means that for the vast majority, they are killing themselves with unregulated carbohydrate intake.
"It's an area worthy of rigorous study, that is if Pharma doesn't submarine the investigation."
The vast majority of NBC's advertising revenue comes directly from the pharmaceutical industry. If they are crapping on CBD, they are only doing so because that's what the pharmaceutical industry has directed them to do.
Otherwise, NBC would have spiked the story. Nothing that NBC News does hurts the pharmaceutical industry. They are controlled by it, via their outsized advertising revenue.
former law clerk - you really think that is true?
All CBD fans step forward to question the science.
The rise of CBD puzzles me. Have there ever been any documented benefits of CBD?
what about alcohol? Well Atkually, the vast majority of people can drink significant amounts of booze for years and not damage their livers. And most people can booze it up till age 35-40 without any significant health effects. After that.....
Jack kerouac, who I just read about, got drunk every night on a more or less regular basis from age 18-48. Then he got cirrohis of the liver and died. Also see Chris Hitchens. Hemingway was an even bigger drunk, and made it to 62 without liver damage.
Lots of people make $$$ off CBD and MJ. They don't want to admit its bad for you. Cuts into the profits.
“ All CBD fans step forward to question the science.”
Not me. I start with the rebuttal assumption that everything the Left gets passionately behind is probably bad for you.
The CBD stores in Boulder - many have closed.
I don't think it works very well. and now this?
I developed some storage liver symptoms a few years ago. Found during routine blood work. I have stage 3 inflammation of the liver. Good news - my numbers have come down.
I think it's all the pollution in our bodies from the modern age and china not giving a shit.
had to have a liver biopsy. ugh - that was horrible.
I'm neither pro nor anti cannabis, but I remain gobsmacked by how little serious research has been done on its medical effects. Of the research that has been done, a very large portion is of poor quality.
I say this as someone who helped a medical cannabis company build its technology stack around a decade ago. It may have been when I first started to think that laws and common sense no longer mattered. Very cool people and a lot of fun, but the veneer of science was more important than the science itself.
For those pointing fingers at the pharma industry: mostly the industry doesn't care, since CBD and medical cannabis are generic. Therefore, there is no incentive to research its safety. The traditional pharma industry did spend quite a lot of money on research into specific cannabinoids around twenty years ago, but it generally was not productive. There's still some work being done.
I am not a CBD fan, but I always question the "science."
Is aminotransferase only a marker of liver cell damage or inflammation? And is CBD the only correlating factor?
Science is about asking questions.
CBD--and cannabis--have been around for a while. Is this the first study that's been done?
Everything in moderation, people. Anything in large doses will not be good for you. Your body doesn't need this stuff.
I was never a heavy drinker. Not even a close. but - non-alcoholic liver disease is also on the rise.
Over the course of four weeks, 201 volunteers received either 5 mg per kilogram of body weight (approximately 2.3 mg per pound or the equivalent of 350 mg for a 154-pound individual) of oral CBD, or a placebo. The goal was to give them a typical amount that might be used by consumers. Participants also underwent weekly laboratory assessments.
201 people (201? Why 201?) over 4 weeks. Some "study."
Yes, I question the "science."
I went to see a few specialists. One thing I was warned about --> Americans love to self-medicate with herbs. He warned me about that, and told me to stay away from herbs.
Obamacares. Caveat emptor.
typos galore. I still have this crap keyboard with liver disease.
"the equivalent of 350 mg for a 154-pound individual) of oral CBD"
Based on chat GPT, average dose for people would be 5-20 mg. I am not surprised 10+ times the average dose of anything might be problematic.
Ocean: "Jack kerouac, who I just read about, got drunk every night on a more or less regular basis from age 18-48. Then he got cirrohis of the liver and died. Also see Chris Hitchens. Hemingway was an even bigger drunk, and made it to 62 without liver damage."
A New Statesman columnist got hold of Winston Churchill's menus and liquor-store bills and calculated what Winston drank on a typical day. Then he set out to spend a day drinking like Churchill. Started with a whisky and soda upon rising.
He never really got drunk during the experiment, but all he could do at the end was sit on the sofa and watch Death in Paradise.
Winston lived to be 90.
GSTK
JSM
350mg/day is a shockingly high dose.
I recently suffered what I think were withdrawal symptoms after I stopped a 2+ week (4 a day) use of Tylenol for pain after a fall. Lethargy and irritability for a few days.
The people who sell CBD recommend 15-25 mg, up to 90 mg max daily. Old and slow is correct.
https://www.cornbreadhemp.com/blogs/learn/cbd-gummies-dosage-guide?srsltid=AfmBOoqYQ1KOMh2IBduwoAAfTDGGrYM9n4NMmpiH4Q8nSakpQzPpVL5L
Tylenol is bad for the liver.
I like Biff's response.
I wonder if they will do a similar study about THC? I'm no expert and I honestly don't know the exact difference between CBD and THC. (All I know is that CBD is not supposed to get you high.)
Another thing: I wonder if any other factors could have influenced this study. I was on a jury once with a medical doctor and she said that when a patient tells her how much alcohol they drink, she always multiplies it by four.
The plastic surgeon who regularly cuts precancerous lesions out of me told me that most oxycodone addicts die from liver problems from the acetominophen rather than from the oxy. He rarely prescribes anything stronger than motrin. He's of the "rub some dirt on it" school.
loudogblog said...
Another thing: I wonder if any other factors could have influenced this study. I was on a jury once with a medical doctor and she said that when a patient tells her how much alcohol they drink, she always multiplies it by four.
7/10/25, 12:08 PM
From now on, whenever I get a prescription I am going to reduce the dose by four to cancel things out.
Per Grok:
There's no single "average" CBD dosage, as it varies greatly depending on individual factors and the desired effect. However, a common starting point for beginners is 10-20 mg per day, gradually increasing until the desired effect is achieved. Some users may find relief with doses as low as 20 mg, while others may require upwards of 100 mg or more
Like everything else in this universe, the dose makes the poison. Acute and chronic dosages are completely different animals. Chronic use of anything powerful is not a particularly good idea.
The article is unclear whether the 350mg was weekly for four weeks or daily for four weeks. Typical journalist would be hard-pressed to understand the difference, much less appreciate the significance thereof.
BTW, Grok tries to minimize the risk by stating that its "only" 5.6 percent that got liver damage and that "its asymptomatic and easily reversible". First moderate liver damage is usually asymptomatic - when you start getting symptoms you've incurred a lot of damage. Second, there's no proof that any of this is "easily reversible" - maybe it is. Maybe its not.
Finally, this is only a 4 week study. Imagine the damage if you did this for 40 weeks.
The article is unclear whether the 350mg was weekly for four weeks or daily for four weeks.
Yep. I had to do my own research to find out its 350mg per day. And this is considered "Low to moderate" for clinical usage.
These same people tell you to take Statins.
You all should go and look at what Statins do to your liver.
Yawn. "Science" is so easy to manipulate.
Gemini AI: As an Alternative to Statins: For individuals who cannot tolerate statins due to side effects or other reasons, Metamucil, in conjunction with a healthy diet and lifestyle, may offer a viable alternative for managing cholesterol.
That's the rub with CBD. For it to be effective it has to be at a relatively high dose. If you took 350 mg of THC per day you would be a drooling zombie living in your mother's basement wearing a diaper.
Howard said...
Gemini AI: As an Alternative to Statins: For individuals who cannot tolerate statins due to side effects or other reasons, Metamucil, in conjunction with a healthy diet and lifestyle, may offer a viable alternative for managing cholesterol.
The cholesterol hypothesis is dead. They don't even defend it anymore. The original science underlying it would make Mendel blush.
Cholesterol is a basic building block for most cells in your body. It is particularly necessary for brain function. 75% of the cholesterol in your body is produced in your liver. It is highly regulated. Diet has nothing to do with cholesterol levels.
Statins are the biggest snake oil scam in history.
Achilles said...
The cholesterol hypothesis is dead. They don't even defend it anymore. The original science underlying it would make Mendel blush.
***************
Can you provide us with peer-reviewed evidence to support that assertion? The American Heart Association is still stressing dietary management.
"Choose foods that are low in saturated fat, trans fat, sodium (salt), and added sugars"
"Limit saturated and trans fats. Avoid high-fat processed and convenience foods"
Achilles said...
The cholesterol hypothesis is dead. TO ACHILLES
They don't even defend it anymore. THAT ACHILLES HEARS
The original science underlying it would make Mendel blush.
IN ACHILLES MIND
fify!
CBD is basically hemp extract. Under the 2018 Agriculture Improvement Act, it can be sold with virtually no regulations, as long as it contains 0.3% or less of THC (the main psychoactive ingredient in pot).
While the pot connection gives it a certain cachet, CBD is probably no more effective for pain, inflammation or other health conditions than any other nutritional supplement. And while this isn't widely known, a lot of nutritional supplements can harm some users' livers in high enough doses -- including basic ones like turmeric or green tea.
Controlling blood sugar is the ticket to prevent cardiovascular disease.
Gemini AI: "Yes, Metamucil can help lower blood sugar levels, primarily due to its psyllium fiber content. Psyllium fiber forms a gel in the digestive system, which can slow down the absorption of sugar, helping to maintain healthy blood sugar levels. "
Apples and oranges, Ted.
Gemini AI: Hemp oil and CBD oil, while both derived from the cannabis plant, differ significantly in their composition and intended uses. Hemp oil is primarily extracted from hemp seeds and is rich in essential fatty acids, vitamins, and minerals. CBD oil, on the other hand, is extracted from the flowers, leaves, and stalks of the hemp plant and contains higher concentrations of cannabidiol (CBD), a cannabinoid known for its potential therapeutic benefits.
The cholesterol hypothesis is dead. They don't even defend it anymore. The original science underlying it would make Mendel blush.
Gregor Mendel does not deserve your slam. Contrary to some people's mythology, he did excellent science—a third of a century before anyone was prepared to accept the results. Then, in one year—1900—3 people independently confirmed and duplicated his results in heredity.
effinayright said...
Achilles said...
The cholesterol hypothesis is dead. They don't even defend it anymore. The original science underlying it would make Mendel blush.
***************
Can you provide us with peer-reviewed evidence to support that assertion? The American Heart Association is still stressing dietary management.
"Choose foods that are low in saturated fat, trans fat, sodium (salt), and added sugars"
"Limit saturated and trans fats. Avoid high-fat processed and convenience foods"
The problem is this only works on people who don't think for themselves.
75% of the cholesterol in your body is produced by your liver. That is why Statins "work." Your diet has very little to nothing to do with cholesterol levels.
All of the "low fat diet" bullshit came from the Sugar industry who literally paid for all of that peer reviewed "research" you are referring to. And almost all of that peer reviewed "research" on diet is based on survey data.
These are the same researchers who came up with masks stop COVID and 6 foot distancing research.
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