"For almost a century, scientists have known that people with schizophrenia struggle to regulate their body temperatures."

"In the 1930s, two doctors in Worcester, Mass., placed people with and without schizophrenia in a small, windowless room with eight electric heaters. Under hot conditions, the researchers noted, the patients with schizophrenia’s body temperatures rose farther and faster than the control group. 'Schizophrenic subjects,' they wrote later, 'are unable to comply normally … with the regulation of heat.'... Schizophrenia has also been linked to problems regulating dopamine, the chemical that makes the body feel good; altered levels of dopamine can also prevent the body from effectively cooling itself off.... Many antipsychotic medications... also make their users more sensitive to heatstroke....Then there is the tendency of patients with schizophrenia to wrap themselves in layers upon layers of clothing, even in boiling temperatures.... Experts also say that people with schizophrenia lack insight into themselves and their condition — in medical terms, this is known as 'anosognosia.'... Under psychosis, a patient might walk for miles engaging only with the voices and characters in their own mind. Under normal conditions, that might simply be dangerous. In Phoenix, it’s deadly."

From "The unexpected reasons that extreme heat is so dangerous for those with schizophrenia/Schizophrenia may be the deadliest preexisting condition during heat waves. The fate of one man in America’s hottest city shows why" (WaPo)(headline at the front page. At the article page, it's "Heat's Hidden Risk").