"Another way in which antidepressants may work involves the enhancement of neuroplasticity..."

".... or the brain’s ability to reorganize its structure and connections. Continued treatment with antidepressants may bolster brain chemicals and processes that promote neuroplasticity. (Psychedelics are thought to work as a treatment for depression and anxiety, in part, for a similar reason.) The hypothesis is that the drugs open a 'window' of plasticity through which the brain has a renewed ability to change the way it is wired. Patients treated with antidepressants often feel more mentally malleable and better able to move away from unhelpful thinking patterns. Some researchers have proposed that we should think about antidepressants as relieving a kind of cognitive constipation."

From "Millions Use Antidepressants. We Still Don’t Understand How They Work. Here’s how psychiatrists like me think about the most promising hypotheses" (NYT).

"My hair stood on end and I became ferocious and, like, this is not happening, but I had nowhere to hide."

WATCH: Hayden Panettiere says she was 18 when a woman she trusted as a protector took her below deck on a yacht and physically put her in bed beside an undressed “very famous” man.

“By the time I’d realized I was in danger, I was quite literally out to sea.”

“She physically put… pic.twitter.com/rz5JAyxQo0

— Scott M (@EODWX5) August 17, 2026

Background: "Hayden Panettiere, Star of ‘Nashville’ and ‘Heroes,’ Dies at 36/In May, she published a memoir after a tumultuous decade that involved depression, substance abuse, losing custody of her daughter and stints in rehab" (NYT gift link).

UPDATE: From  "Emergency Responders Found Hayden Panettiere in Cardiac Arrest/After the authorities responded to a 911 call in Greenville, S.C., an initial police investigation found no evidence of 'foul play or suspicious circumstances'" (NYT gift link):

The cardiac arrest was caused by an apparent drug overdose, according to a person with knowledge of the situation... The person with knowledge of the situation said that Ms. Panettiere was with Brian Hickerson, a former boyfriend, at the time of her death.... 

According to Ms. Panettiere’s memoir, 'This Is Me: A Reckoning,' which she published this year, she met Mr. Hickerson in 2018 in Los Angeles. The two dated on and off for several years. Court records show that in 2021, Mr. Hickerson pleaded no contest to two felony counts of injuring Ms. Panettiere." 

"The right-wing De la Espriella, who was inaugurated last week, pledged during his campaign to bring the 'wrath of God' against drug traffickers and other armed groups to 'end them like cockroaches, like rats.'"

From "Colombia’s new president asks Trump to bring militarized antidrug campaign to the country/The South American nation is the world’s largest producer of cocaine" (WaPo).

"Margaret Thatcher’s government spent £100,000 on a top-secret plan to 'bomb' Peru with voraciously hungry moths in a radical attempt to destroy cocaine crops."

The London Times reports.

The method is relatively cheap and simple. From what is known of Eloria [noyesi] it might be thought of as a ‘smart bomb’ with a very short range."...

 
"The moth is indigenous to Peru and is highly host-specific to the coca bush. There is no evidence of it feeding on other plants … Its use as a control agent could, therefore, be concealed."

I wonder what else has been going on in the use of tiny animals in warfare. I found this, at the History website: "Bugs of War: How Insects Have Been Weaponized Throughout History/For millennia, six-legged soldiers have been conscripted to torment enemies."

At the end of the 2nd century, the Roman emperor Septimius Severus was on his way to wresting control of Mesopotamia from the local monarchs.... As the Roman legions advanced on the desert stronghold of Hatra.... The defenders crafted earthenware bombshells loaded with scorpions.... As Severus’s men reached the walls of Hatra, scorpion bombs rained down....

More recently: 

During the Vietnam War, the Viet Cong dug a network of underground tunnels allowing them to decide when and where to fight.... Feeling his way through a dank passage, [an American] “tunnel rat” might overlook a trip wire and have a load of scorpions rain down from a hidden cavity in the roof. The Viet Cong also conscripted the Asian giant honeybee.... Soldiers gingerly relocated colonies to trails used by the Americans and then attached a small, explosive charge.... For their part, the U.S. military funded a research program to devise an apparatus to spray the Vietnamese enemy with the alarm pheromone of bees, thereby converting the local insects into fierce allies.... But the “weapon” was never deployed....

AND: Wikipedia has an article, "Entomological warfare."

Entomological warfare (EW) is a type of biological warfare that uses insects to interrupt supply lines by damaging crops, or to directly harm enemy combatants and civilian populations. There have been several programs which have attempted to institute this methodology; however, there has been limited application of entomological warfare against military or civilian targets, Japan being the only state known to have verifiably implemented the method against another state, namely the Chinese during World War II. However, EW was used more widely in antiquity, in order to repel sieges or cause economic harm to states. Research into EW was conducted during both World War II and the Cold War by numerous states such as the Soviet Union, United States, Germany and Canada. There have also been suggestions that it could be implemented by non-state actors in a form of bioterrorism. Under the Biological and Toxic Weapons Convention of 1972, use of insects to administer agents or toxins for hostile purposes is deemed to be against international law.

A poster from 1942:

"Every time we find out something new about GLP-1, it's a positive.... They're now saying that it reduces the likelihood of stage one cancer going to metastatic cancer..."

"... by 50%. Every time we keep waiting for another shoe to drop, we find out, 'Oh, it's actually a good thing.' Everyone at this table is going to be on a GLP-1 within 24 months....  I think when you look at the studies around the upside versus the downside here, it's the most transformative technology in the world."

Says Scott Galloway, ticking off Bill Maher:

Bill Maher shuts down Scott Galloway on the spot after he says “everyone should be” on a GLP-1 “within 24 months.”

GALLOWAY: “Every time we find out something new about GLP-1, it's a positive. They're now saying that it reduces the likelihood of stage one cancer going to… pic.twitter.com/2KUMXrkciF

— The Vigilant Fox 🦊 (@VigilantFox) August 1, 2026

AND: Speaking of Scott Galloway...

Scott Galloway is upset about being 'doxed' after he supported Mamdani's pied-à-terre tax:

"He's taken a legitimate source of tax revenue, and he's turning it into a wanted poster."

"What is the upside here? Why is he doing this?"

Incredible. pic.twitter.com/9Yrb9lw4An

— Western Lensman (@WesternLensman) August 1, 2026

"These aren’t like some vague hallucinations, these are like three-dimensionally-rendered, highly-detailed figures inhabiting your exterior world."

"And they’re also interacting with objects in the real world — like crawling up chairs and tables or under doorways.... The little people are said to typically like teasing, playing with or harassing the person seeing them.... Everyone knows that this mushroom has this property and can make you see little people, but they’ll continue to eat it anyway, because they’re just not afraid of that effect."

Said University of Utah researcher Colin Domnauer, quoted in "New magic mushroom makes users see tiny ‘gnome’ people — scientists have no idea how it’s doing that" (NY Post).

The mushroom is L. asiatica.

Would you want to see little people running around everywhere?

I remember hearing Joe Rogan talk about this and speculate that the people are somehow really there....

"You know the thing is like is it teaching us something about the human brain or is it allowing you to see something that's actually there all the time?"

"I want to acknowledge that the conversation that RFK is trying to have and that we’re having here is not theoretical for me, anyway. And here I’m going to shake my Lexapro."

Says the host of the NYT "Daily" podcast, Michael Barbaro, in yesterday's episode, "R.F.K. Jr.’s Newest Mission: Getting Us Off Antidepressants/The process of 'deprescribing,' in which a doctor helps a patient taper off a psychiatric medication, is now being considered in the development of federal health policy."

I’ve been on Lexapro, an anti-anxiety medication, for at least a decade. It was prescribed by a psychiatrist, but then just became part of my relationship with my general practitioner. I just get it renewed. And I’ve not really been asked to think about how long I should be on it. And now suddenly having this conversation with you is making me ask that question. How long am I supposed to be on it? What would happen if I stopped taking it? Would all the white noise of anxiety that made me want to go on Lexapro, would that return? Or 10 years later, have I outgrown that and I just don’t it because I’ve never tried to taper myself off this to find out who I would be if I weren’t me on Lexapro?...

The guest on the episode, Ellen Barry, asks Barbaro, "what did you conclude about stopping?"

Michael Barbaro: "Me? I don’t that I’ve ever gotten far enough along in the conversation with myself to stop.... It was just an accepted fact in my conversation with the doctor that I was on it, and then I’d probably still be on it for as long as I’m going to be on it.... But now I’m asking myself the question of, are we all infantilizing ourselves in the face of medicine? Should I be asking this question myself? Why should I be waiting for a doctor to ask it? It’s getting a little existential now."

If Michael Barbaro, a man whose whole career is about being thoughtful about miscellaneous things, is only thinking of these questions as he's in the middle of doing his podcast on the subject, what hope is there for the millions of Americans who take these medications as a matter of endless routine?

"Well, now we finally know what would happen if The Wall Street Journal and Us Weekly had a baby. In a piece titled 'Everyone in Trump’s Cabinet Is Eating Sauerkraut'..."

"... the Journal reports that various White House officials are shedding pounds thanks to a hot new diet that involves eating lots of fermented foods, like sauerkraut and kimchi.... There’s just one drawback: 'sulferous odors' have caused some 'friction at home.'... HHS secretary Robert F. Kennedy Jr. was, naturally, the first to jump on the trend. Now he’s converted Commerce secretary Howard Lutnick, Transportation secretary Sean Duffy, and Vice-President J.D. Vance. We’re told that the men have been getting compliments on their 'glowing skin' and seeing various health benefits, including dramatic weight loss.... [S]everal Cabinet members have been looking svelter, and what other explanation could there be? It’s not like there’s some new magical weight-loss drug out there!"

Writes Margaret Hartmann, in "Sure, the Trump Cabinet’s Weight-Loss Secret Is Definitely 'Sauerkraut'" (New York Magazine).

"As the president walked off the stage, he whispered to his wife, 'I really f**ked up, didn’t I?' she writes. '"Yes, you did,'" I whispered back.'"

I'm reading "5 Revelations From Jill Biden’s Upcoming Memoir" (Intelligencer).

I don't believe any of it. She said that during the debate, as she watched it on TV, she thought he might be having a stroke and that he'd never acted like that before or since. Sorry. Not believed. I think the new book exists to be sold — to make money — and to try to escape responsibility for depriving the American people of the power to participate in the selection of the Democratic Party's 2024 presidential candidate.

"To this day, I still don’t know what happened. Why wasn’t he making any sense? It was inexplicable to me," she says elsewhere in the book. Maybe he had rehearsed too much? Maybe he had traveled too much that month? Or was he just ill? The president had seemed exhausted earlier in the day and had told her that he was not feeling too well. Later, after positing that he may have unwittingly taken codeine cough syrup or Ambien to fight off a cold or to help him sleep, Jill Biden seems to rhetorically throw her hands in the air: "I only wish I had the answer."

"GLP-1 drugs may be rewiring circuits involved not only in appetite but in emotion, desire and beyond."

WaPo reports. Gift link. Excerpt:

Tens of millions of people are now taking the medications worldwide, turning what began as an obesity and diabetes treatment into what could be modern medicine’s largest unplanned neuroscience experiments. Scientists are studying GLP-1 drugs — medications that mimic the hormones involved in appetite, blood sugar and digestion — for how they affect not only eating behavior, but also addiction, cognition, neurodegeneration and even motivation and pleasure....

On social media and at doctor’s offices, some users have reported a type of brain fog and others something broader and harder to define: a strange emotional flattening. People describe less pleasure, less motivation, diminished interest in hobbies and even reduced sexual desire. Those accounts are beginning to raise deeper questions about what, exactly, these drugs are changing. If GLP-1s alter the brain systems involved in reward, craving and motivation, researchers wonder, where is the line between quieting a person’s destructive impulses and reshaping personality itself?...

"Just as the Founding Fathers might have anticipated (had they been microdosing while drafting the Declaration of Independence)..."

"... the American republic will celebrate its two-hundred-and-fiftieth anniversary next month with a full card of mixed-martial-arts brawls on the South Lawn of the White House. Weigh-ins will take place at the Lincoln Memorial. The night of mayhem is also meant to celebrate the eightieth birthday of the President of the United States, a longtime fan of the sport...."

So begins "Dana White Thinks Everyone’s a Fighter/The U.F.C. president on his decades of friendship with Donald Trump, his relationship with Joe Rogan, and his 'awesome' night at the White House Correspondents’ dinner" in The New Yorker, written by David Remnick.

I wanted to quote that here because I feel as though I'm seeing a trend in Trump-hating writing. There's a choice to couch descriptions within a problem of the distortion of reality. In this article we have the idea of the Framers microdosing. Last night, I blogged a WaPo writer saying "at least half of life with RFK Jr. feels like something you dreamed"... though "It sure feels real in your lower intestines, doesn’t it?"

Why did the writer take us inside her body like that? It's one thing to say my mind is off, I feel like I'm on drugs or I must be dreaming or maybe I'm crazy, but it's another thing to invite us into the nether regions. People often speak of their "gut reaction," but it's rather intimate to bring up "lower intestines." At least we're not directed to think about the colons of the Founding Fathers.

Anyway, speaking of getting physical: mixed martial arts. Mixed martial arts for the celebration of America's "two-hundred-and-fiftieth anniversary next month." Next month is June. The 4th of July is in July. But the fighting on the White House lawn is June 14th. That's Trump's birthday. Can't he have what he wants?

What did George Washington do on his birthday? It's 4 in the morning, and I'm writing this wide awake and sober: I'm going to guess nothing.

History in the making 👀

New visuals for #UFCWhiteHouse and the UFC Freedom 250 Fan Fest are here!

[ Presented by @Cryptocom & @RamTrucks ] pic.twitter.com/PQP7dut7fE

— UFC (@ufc) May 23, 2026

"Some psychiatrists said they worried that Mr. Kennedy’s deprescribing initiative was the beginning of a wider effort that might, in later stages, discredit psychiatry more broadly and restrict access to care."

"'I think it is actually putting more questions in people’s minds about whether psychiatric treatment is safe or effective,' said Dr. Eric Rafla-Yuan, who chairs the [American Psychiatric Association's] caucus on the social determinants of health. 'The data has not changed on S.S.R.I.s. It’s the narrative that has changed.' He said the A.P.A. should be pushing back forcefully against Mr. Kennedy’s claims about psychiatric treatments, and should steer clear of seeming to endorse any part of the initiative. 'It’s a fine line between having a seat at the table and being used as a tool to legitimize their agenda,' he said."

From "Kennedy’s Push to Curb Antidepressants Has Shaken Psychiatry/An annual psychiatric meeting was abuzz over Robert F. Kennedy Jr.’s call to rein in the use of depression medications. Some fear it will drive patients away from care" (NYT).

"AJ Jasper, 40, has been struggling with anorexia for about 30 years. Three years ago, at a time when he was a healthy weight, he relapsed after purchasing GLP-1s..."

"... from various apps without ever seeing a doctor. Using multiple drugs at once, he dropped 50 pounds within three to four months. 'The apps make it frighteningly easy. It is like anorexic heroin to my brain chemistry,' said Jasper, a social worker in Chicago. This past winter, he went into triple organ failure — his kidneys, liver and heart were all affected — leaving him too weak to walk or even turn in bed at times...."

From "People with eating disorders are taking GLP-1s and doctors are alarmed/Providers said some patients with anorexia, bulimia and binge eating disorders are taking GLP-1 drugs" (WaPo).

"But when you said the mental is the problem in drugs — 'cause the people don't want to be down there."

"My daughter is schizophrenic and she's on crystal meth — so that hit home — so if you're going to do that, you got my vote.... 'cause Karen Bass is not doing shhhh. Absolutely nothing."

"Around 1980, mainstream psychiatry adopted a medical model."

"A new edition of the Diagnostic and Statistical Manual of Mental Disorders, U.S. psychiatry’s bible of diagnoses, published that year, enshrined the change. Ever since, troubles of the mind have been viewed mostly as physiological diseases of the brain, with treatments focused largely on pharmaceuticals. The medical model was partly a reaction against psychiatry’s decades-long dominance by psychoanalysis and its offshoots.... The discipline, meanwhile, was under attack in popular culture; the antipsychiatry movie 'One Flew Over the Cuckoo’s Nest' won five Oscars in 1976. The field wanted to be viewed as a true science. Then Prozac, an S.S.R.I., was released in the United States in 1987.... The idea of Prozac — and, soon, its close S.S.R.I. cousins — as an unmitigated medical advance was spread by a flood of pharmaceutical advertising. The ads presented readily comprehensible brain science: Mental illness boils down to an imbalance of chemicals.... The chemical imbalance theory has never been substantiated and has been supplanted by other hypotheses that are equally elusive to proof...."

From "The Strange Alliance Trying to Remake American Psychiatry" (NYT). By Daniel Bergner, author of "The Mind and the Moon: My Brother’s Story, the Science of Our Brains and the Search for Our Psyches."

"They said garage bands are coming back with kids, which is kind of means nature is healing."

From a Joe Rogan conversation that starts here:

From the transcript, which blends the voices of the 4 interlocutors: "It's so sad that rock is dead.... We were talking about that. Yeah, it's all queefy now. When was the last time.... Where's the new rock bands? The new Zeppelin... It used to be the biggest part of music. Rolling Stones, AC/DC.... It used to be the biggest part of music was rock and roll. What the fuck? That's kind of crazy.... What happened to rock? What happened to rock? Who are the biggest? They said garage bands are coming back with kids, which kind of means nature is healing. Yeah, that's a good sign.Yeah, kids are tired of playing video games. Want something real. But the thing about that that doesn't make sense about rock music is everybody still loves it, right? Everybody still plays covers. Oasis is doing giant arenas all over the place. I took acid at that Oasis concert...."

And that last line changes the topic. Too bad! I wanted to hear more about the return of garage bands and why that's a sign of health, but then I understand the argument. I just wanted to spend more time on it and on Joe Rogan, it seems they take every opportunity to get back onto drugs. 

"Tucker Carlson... has called the nicotine pouch brand ZYN a 'lifesaving' product that can increase productivity and 'male vitality.'"

"Mr. Carlson went so far as to say that the pouches are 'like the hand of God reaching down and massaging your central nervous system.'...  'What the Make America Healthy Again movement is saying is, "I am going to question what I’m told," said [biohacking influencer Dave Asprey,] who has encouraged his followers to do their own research on and experiment with nicotine, which he calls one of 'Mother Nature’s cognitive enhancers.'... Another common refrain among MAHA supporters is that the medical establishment has made Americans sicker by suppressing information about natural cures and instead pushing prescription medications. That was the focus of an episode last year of the popular 'Culture Apothecary' podcast, titled 'Nicotine is NOT the Villain: What Big Pharma Hides from Parents.' Alex Clark, the podcast’s host and a leading figure in the MAHA movement, interviewed a chiropractor and alternative medicine practitioner who suggested that the drug industry had buried information on nicotine’s benefits and claimed that nicotine could treat Covid, cancer and more...."

From "Influencers Are Spinning Nicotine as a ‘Natural’ Health Hack/The influencers, many of them aligned with the Make America Healthy Again Movement, say the medical establishment has unfairly demonized the compound" (NYT).

like the hand of God reaching down and massaging your central nervous system — reminds me of that Trump-is-like-Jesus illustration:

Jordan Peterson and akathisia.

We figured out that dad has a psych med induced neurological injury, and has been suffering from akathisia. It’s been 6 years since any psych medications. Last summer his symptoms started, after a flare up likely induced by mold (CIRS) and stress. It was complicated by pneumonia… pic.twitter.com/wPjAz4XsLT

— Mikhaila Peterson (@MikhailaFuller) April 18, 2026

"I got a call from a number of people, including the great Joe Rogan, and he said we have to do something about this."

"And I looked into it. I called Bobby... And it was really uniform support. And I said, so why would we wait three or four years to get it done?... Let's get it done immediately. And that's what happened. This is probably has never been anything that happened so quickly. Everybody is so strongly in favor of this. It's for a lot of people, but it's for the military in particular...."

"I want to thank Secretary of Health and Human Services, Robert F. Kennedy Jr., who is fantastic.... And people love him. More importantly, your wife is here.... Real boss in the family. It's fantastic.... Joe Rogan — fantastic. We did an interview before the election. We had over 300 million people. And I said, oh, man, I hope Kamala doesn't do it and she didn't. He wanted her to do it and she didn't Some day, Joe's gonna explain why. I can tell you why. Because she didn't want to.... The executive order I'm signing... today.... directs the FDA to expedite their review of certain psychedelics already designated as breakthrough therapy drugs.... If these turn out to be as good as people are saying, it's gonna have a tremendous impact on this country and other countries too.... Usually with things like this, nothing ever happens, no matter how the research ends up. We're changing that...."

ADDED: Joe spoke:

🚨 WOW! Joe Rogan reveals President Trump IMMEDIATELY offered him FDA approval for a psychedelic treatment in a text chain

Because the data was SO CONVINCING and STUNNING

"I wanna tell everybody how this happened. I send President Trump some information."

"With one dose of… pic.twitter.com/dnqYVf96hN

— Eric Daugherty (@EricLDaugh) April 18, 2026

"Androgenic Reacts After Reports Of Clavicular Suspected Overdose."

A Newsweek headline. Can you even read it?

I know Clavicular is a person, and I've got to presume Androgenic is also a person. By their names alone, I would have guessed they were corporations or health-care products of some kind. But in the context — reacting, overdosing — I can see that they are human beings. Sad.

Clavicular is only 20, and he's gotten far too much attention for a young person. Yes, he's been asking for it, but don't give young people everything they ask for.

Sample paragraph from his Wikipedia page: "On December 27, 2025... [Clavicular] described Vice President JD Vance as 'subhuman' for his "recessed side profile' and for being 'obese,' asking, 'How are you fat and expected to lead a country?' He agreed with [a] criticism of California governor Gavin Newsom as both a 'degenerate' and a 'liar' but said that, in a potential 2028 United States presidential election in which Newsom ran against Vance, he would vote for 'Chad' Newsom for 'mogging,' or being more attractive than, Vance."