"... compared with people who rarely stood.... In theory, being upright should stave off this harm, since it’s the postural opposite of sitting.... But surprisingly little credible science supports all this verticality, and some studies have raised doubts.... [A]s you stand still, blood flows through your legs sluggishly at best and often pools there, potentially contributing to circulatory disease. You also barely raise your heart rate, which is necessary to improve cardiovascular health...."
I have a motorized stand/sit desk. I recommend switching from sitting to standing and from standing to sitting whenever you notice that you feel a bit uncomfortable. Be in touch with your own feelings.
And by the way, is standing "the postural opposite of sitting"? I was going to say no, but then I remembered...