"Weight loss is easiest at the beginning, before your body starts actively working against it."

"'Your brain doesn’t know you’re trying to lose weight on purpose... it thinks that something is wrong.'... First of all, you become hungrier, obviously. And not just because you want to eat as much as you did before; you actually want to eat more than you did prior to losing weight. 'With every one kilogram you lose, your appetite goes up above baseline by 90 or so calories per day'.... At the same time, your body looks for ways to conserve energy. Your muscles work more efficiently... so walking that normally burned 100 calories might now burn only 90. By making you want to eat more and burning fewer calories, your body is eventually able to slow weight loss down to zero. Here is your plateau. This is, all told, a remarkably elegant and robust system, if what you wanted to do is to maintain your weight."

From "The Ozempic Plateau/Everyone hits a weight-loss plateau, but the race is on for next-generation drugs that can help patients lose even more weight" (The Atlantic).