২৫ মার্চ, ২০১৮

"[Sion] Jair has heard the advice that you should test yourself mentally, do sudoku, crosswords and the like. But this doesn’t work for him."

"Not long ago, he tried to do a 'coffee time' crossword. He did it every day, in five minutes. But now he just stared blankly at the newspaper. 'Do you know, I couldn’t do two or three clues,' he says, shaking his head. 'So all that did was discourage me.' When he reads, Jair finds that he has forgotten the start of a sentence by the time he’s finished it. Nevertheless, as we wind our way up the Old Man [mountain], he has a precise recall of events that took place 50 years ago, even down to very specific details about the one-month Outward Bound course that first brought him to the Lake District. 'I had quite a good memory in the past,' he says. 'But that’s ironic, isn’t it? I can remember that my memory was good, but I can’t remember what about.' ... The future, when Jair thinks about it, can be a bit scary. He has no family, no companion (though he’d dearly like one); the one thing that’s always there for him is the Old Man of Coniston...."

From "Meet the man living with Alzheimer’s who climbs the same mountain every day/Sion Jair, 68, has climbed the Old Man of Coniston at least 5,000 times and the emerging science backs him up that regular, vigorous exercise is beneficial for those with the disease" (The Guardian).

১৯টি মন্তব্য:

mockturtle বলেছেন...

My husband didn't have Alzheimers but had Lewy Body Dementia [as did Robin Williams, IIRC]. He did the ridiculously difficult Cryptic Crosswords from the Telegraph, which I printed off for him daily, per subscription, well into the disease. Memory wasn't so much an issue for him early on. Rather he experienced hallucinations, delusions and difficulty with visuospatial perception and executive function.

I do a NYT Sunday puzzle in a book every day because I enjoy it, not because of any illusions that it will keep my brain healthy.

madAsHell বলেছেন...

My wife's grandfather only spoke Spanish, but would wander the hills on the west side of Porland, Oregon. He would carry a card with his address, and people would point him in the correct direction.

This came to a stop, when he asked "Does a goat have three legs, or four?"

Yancey Ward বলেছেন...

My father has both Alzheimers and Lewy Body Dementia. Both are ugly, ugly diseases.

Rabel বলেছেন...

The article gives the impression that a "brain scan" can provide a definitive diagnosis of Alzheimer’s disease. This is incorrect.

tcrosse বলেছেন...

It's a hideous realization that being the caregiver for a person with Alzheimers does not make you immune to getting it yourself.

Yancey Ward বলেছেন...

Rabel, I read the story at the link, and my impression is that Jair's case of Alzheimers is fairly mild at this point. He reminds me of what my father was like a couple of years ago- suffering losses of cognitive ability, but still able to function every day and appear to have suffered no losses at all to anyone not intimately familiar with him.

Yancey Ward বলেছেন...

tcrosse,

Yes- I wonder what my fate will be. My father's mother suffered like he did. On the plus side, though, my mother's side of the family doesn't appear to suffer from it at all. I am praying I am more like my mother than my father.

Howard বলেছেন...

I told my kids if I ever get Alzheimers to dress me in appropriate clothes and let me wander the forest with a gps tracker.

Fernandinande বলেছেন...

"regular, vigorous exercise is beneficial for those with the disease"

Regular vigorous exercise is good for people - who knew?

mockturtle বলেছেন...

Per Rabel: The article gives the impression that a "brain scan" can provide a definitive diagnosis of Alzheimer’s disease. This is incorrect.

Yes, only a brain autopsy can make a definitive diagnosis.

Bruce Hayden বলেছেন...

Never could do crosswords. My late father was an avid crossword puzzler, and died with his compendium of 3 and 4 character hint/answer tuples unfinished. None of his boys had any interest in them. For me, my mind is maybe too literal for crossword puzzles - though I expect that my partner’s mind would do even worse, given how literal her mind is (I still haven’t been able to successfully explain Rock, Paper, Scizzers to her after almost 2 decades).

What I do compulsively these days is play Sudoku. Last summer, I had what might have been a mini stroke. And tested that theory out by playing Sudoku. I found myself making mistakes at a rate significantly above that I usually do. A day or two later, I was back to normal. I can pretty well tell my alertness level the same way - sometimes when I wake up in the middle of the night, and nothing is happening in the blogosphere, I will shift to Sudoku. If I make too many mistakes, I know that I can fall back to sleep. And, if not, I play until that does happen.

Now my partner wants me practicing my memory skills the way that she does, remembering TV trivia. She is constantly quizzing me on wisdom she imparted to me a day or two ago. When I don’t know the answer, she tells me to “think”. And won’t change the subject until I have it. But memorizing random nonsense has never been my forte, since I tried to memorize the geological eras in 7th grade. I frankly don’t care which character that actor played in what show in the distant past, so do horribly on her quizzes. And telling her about Sherlock Holmes explaining his disinterest in moon science to Watson doesn’t help my case.

Sebastian বলেছেন...

The scary part of the case is that he appears to have no one to care for him, other than the state.

There'll be many more like him, the atomization of society producing a mass of disconnected old bodies kept alive on sufferance.

William বলেছেন...

Slightly off topic: There's a Stephen King story and movie called "It". In that story a horror that preyed upon children in their youth reappears in their later lives. That's sort of the way it works. I had a reasonably pleasant and comfortable life after the age of twenty five. Nearly all the bad things that happened to me happened before I was eighteen.....I'm now an old man. I find that my most vivid memories are from childhood, and most of them are unhappay. The other memories, including yesterday, are a bland porridge without any defining shape or savor. I recommend to everyone that they have a happy childhood. It makes for a more creative mplacent old age.......I've read that there's such a thing as bliss dementia. You forget all the bad memories. There's an up side to Alzheimer's.

William বলেছেন...

Creative mplacement" was meant to be complacent. That was auto correct not me. Such mistakes have nothing to do with my mental acuity which remains as sharp as ever.

Bruce Hayden বলেছেন...

“Creative mplacement" was meant to be complacent. That was auto correct not me. Such mistakes have nothing to do with my mental acuity which remains as sharp as ever.”

I use the same excuse here all the time. If a comment is filled with one character typing errors, it was probably written on a Windows computer w/o a spellchecker. But if it has some wholly inappropriate words, it very likely was the victim of the IOS spellchecker.

Merny11 বলেছেন...

My Mother died from Alzheimer’s, and my sister is at the advanced stage of it. Both were very intelligent women, voracious readers, active,talented and busy women. You’re either getting the disease or not, no matter what you do. Better to enjoy life while you can. I’ve told my kids to overdose me at diagnosis.

StephenFearby বলেছেন...

In January, I attended a property closing.

The closing attorney mentioned his 70+ year-old mother could easily recall events of her youth but couldn't remember what happened yesterday.

In other words, defective hippocampal memory encoding consistent with either mild or moderate cognitive impairment on the way to full-blown dementia and Alzheimer's.

I quietly slipped him the abstract of my peer-reviewed presentation on what might be done to address this issue...in the context of:

J Alzheimers Dis. 2016;51(4):979-84.

Microbes and Alzheimer's Disease.

"We are [30+ prominent] researchers and clinicians working on Alzheimer’s disease (AD) or related topics, and we write to express our concern that one particular aspect of the disease has been neglected, even though treatment based on it might slow or arrest AD progression. We refer to the many studies, mainly on humans, implicating specific microbes in the elderly brain, notably herpes simplex virus type 1 (HSV1), Chlamydia pneumoniae, and several types of spirochaete, in the etiology of AD [1–4]. Fungal infection of AD brain [5, 6] has also been described, as well as abnormal microbiota in AD patient blood [7]. The first observations of HSV1 in AD brain were reported almost three decades ago [8]. The ever-increasing number of these studies (now about 100 on HSV1 alone) warrants re-evaluation of the infection and AD concept..."

https://content.iospress.com/download/journal-of-alzheimers-disease/jad160152?id=journal-of-alzheimers-disease%2Fjad160152

Since this was published, PubMed has 23 hits for the search: Microbes Alzheimer's.

https://www.ncbi.nlm.nih.gov/pubmed/?term=Microbes+Alzheimer%E2%80%99s

I thought the attorney might have gotten back to me, but he didn't.

Very recently, I spoke to the inventor of the VieLight Neuro-Gamma 810nm anti-inflammatory near-infrared LED headset for which very promising results have been reported by U Toronto researchers in a 2017 case study of moderate cognitive impairment.

He told me that 7 multi-center double-blind studies will soon be registered on Clinical Trials.

The Vielight Neuro-Gamma does not address the cause of brain inflammation but acts like an effective steroid shot (without the negative side effects).

If I speak to the attorney again, I would invite him to consider due diligence on this ($1750 list price) device.

Starting with the interesting basics:

Inventor’s Notes on Whole Brain Photobiomodulation with the Vielight Neuro –
a Transcranial-Intranasal Light Therapy Combination

http://fr.vielight.com/wp-content/uploads/2016/08/Inventors-Notes-Vielight-Neuro-version-2.pdf

Disclaimer: I have no commercial association with Vielight.

I think it may well be useful to (at least temporarily) address brain inflammation in a wide range of brain disorders, including wanna-be school shooters.

Michael বলেছেন...

Stephen Fearby

I have recently discovered the device you mention. Am buying one for my mother in law. There are two versions. Which is recommended. Gamma?

StephenFearby বলেছেন...

@Michael 3/25/18, 7:22 PM

The 40hz (gamma) model was employed in the U Toronto case study.

I believe the manufacturer is still offering an 80% money back guarantee if it is returned before a certain number of months go by. I don't believe that's also the case with their distributors/resellers.

The nutritional approach (to attempt to address shortfalls in immune system competence -- even though these studies didn't address this factor):

Aging (2016)
Reversal of cognitive decline in Alzheimer's disease
https://s3-us-west-1.amazonaws.com/paperchase-aging/pdf/9R5JsRe8k4Jq7uTXj.pdf

The actual ingredients considered for Breseden's "Mend" protocol isn't given in this paper but referenced to:

Aging (2014)
Reversal of cognitive decline: A novel therapeutic program
https://s3-us-west-1.amazonaws.com/paperchase-aging/pdf/NjJf3fWGKw4e99CyC.pdf

Of course, it's a money spinner. Breseden came up with the protocol but apparently didn't like the cut he received from his commercial partner. So he has developed another one that probably is more profitable for him.

At the very least I would recommend considering:

Alzheimers Dis. 2016 Oct 4;54(3):1073-1084.

Cerefolin-NAC Therapy of Hyperhomocysteinemia Delays Cortical and White Matter Atrophy in Alzheimer's Disease and Cerebrovascular Disease.

https://content.iospress.com/download/journal-of-alzheimers-disease/jad160241?id=journal-of-alzheimers-disease%2Fjad160241

But one doesn't necessarily have to have high levels of homocysteine for benefit:

J Am Geriatr Soc. 2014 Aug;62(8):1611-2.
Unexpected recovery of moderate cognitive impairment on treatment with oral methylcobalamin. (One of the three potentially useful components of Cerefolin-NAC as well as the Breseden protocol.)

https://onlinelibrary.wiley.com/doi/full/10.1111/jgs.12966

(Unfortunately, this is behind a paywall, but one can get the drift of what it is about from the preview.)

IMO the combination of the two separate approaches (#1: anti-inflammatory near-infrared light with the Vielight Neuro Gamma) would probably have more efficacy than either approach by itself.

Disclaimer: YMMV